The effect of phenobarbitone on the metabolism of methoxyflurane to oxalic acid in the rat.
نویسندگان
چکیده
The effect of phenobarbitone on the metabolism of methoxyflurane in the rat was investigated. The conversion of methoxyflurane to oxalic acid was confirmed. Pretreatment with phenobarbitone resulted in a further increase in oxalic acid output indicating an acceleration of the biotransformation of methoxyflurane. If the nephrotoxicity of methoxyflurane is secondary to the products of its metabolism, increased microsomal enzyme activity resulting from prior exposure to drugs such as phenobarbitone would predispose to increased toxicity.
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ورودعنوان ژورنال:
- British journal of anaesthesia
دوره 44 12 شماره
صفحات -
تاریخ انتشار 1972